Rumraket
Active Member
It's a probabilistic argument, which you keep showing signs of not understanding. The argument isn't "it's possible - therefore it should". I've already told you that you can rationalize any concievable pattern by simply postulating "that's what the designer wanted". The problem is you don't have any fucking reason to expect the observed pattern on a design hypothesis over any OTHER concievable pattern.lifepsyop said:Again, asserting that because it's "possible" for other trees to exist, means that they should exist if Common Descent is false.Rumraket said:Repeat this simple statement until it sinks in: The total number of possible trees to construct from a limited set of sequences increases exponentially with the number of individual taxons.
Oh yeah, and this small thing here that YOUR DESIGNER HAS NEVER BEEN OBSERVED. (He also seemed wanting to design his creations in MATCHING TEMPORAL ORDER in the fossil record). Creation over billions of years, to make it look EVEN MORE like evolution did it.
In contrast, evolution predicts ONLY patterns like the one observed. And we have SEEN ALL THE MECHANISMS OF EVOLUTION.
Therefore, probabilistically, since no particular pattern is expected on design, but the one observed is expected on evolution, it's simply statistically much more likely.
There are no constraints on the design hypothesis. It predicts nothing. No observation could falsify it. It is a useless model.
What are you even talking about? I've explained in exquisite detail why the observed pattern is a prediction of common descent, but not expected over any other concievable pattern on blanket design.lifepsyop said:The foundation of your whole argument here is illusory. We find a dominant statistical pattern of similarities and differences (from an orthologous dataset ,selected because it is commonly shared) and, like a magician's trick, you automatically claim the mere existence of this pattern is evidence of Common Descent and hope nobody notices.Rumraket said:You take ten loci in one species, say, Homo Sapiens, then you take the ten orthologous loci in Mice, then you take the ten orthologous loci in Cows, then you take the ten orthologous loci in however many species you want. Then you construct a phylogenetic tree for every single one of those ten loci, using the orthologous sequence from all the individual species.
What do you discover? Well shit buddy, they all fucking converge on the same statistical trend, rodents will group together, great apes will group together, bovines will group together, these will all further group together under mammals. Mammals will group with other vertebrates to the exclusion of molluscs, but both will grpup under animalia etc. etc.
And this is despite it being possible to construct UNTOLD QUINTILLIONS of trees from the dataset. Therefore, the theoretical total of divergent trees could outnumber the congruent tress to such an overwhelming degree, there is no expectation to see the convergence we do on probability alone.
There's only one explanation that makes sense and works only with observed mechanisms, that's evolution.
And no, the "re-uses old designs" retort still doesn't make sense for reasons already elaborated upon. For example, there would be no reason to re-design transcription factors, they could simply be kept constant. There'd be no reason to fill up the genomes of living organisms with degrading, inactivated pseudogenes. Or how about thousands upon thousands of retrotranspositionally inserting copies of degrading reverse-transcriptase genes? Just what the FUCK is the purpose if that, if you don't mind me asking? Did the designer WANT it to look like evolution happened?
How come we can do ANCESTRAL SEQUENCE RECONSTRUCTION using the same statistical methods we use to construct phylogenetic trees, RESURRECT ancient protein-coding gene-sequences and get ANCIENT FUNCTIONAL ENZYMES WITH A HIGH DEGREE OF SUBSTRATE PROMISCUITY?
How the fuck would that work on your design hypothesis? We collect the orthologues sequence from multiple species, using known mechanisms of mutation and population genetics, calculate the MOST PROBABLE ANCESTRAL SEQUENCE and splice it into a living bacterium. And what do we get? An entirely different enzyme with a different function.
If common descent wasn't true, there would simply be NO good reason to expect this possibility. You'd have to postulate that protein sequence space just so happens to be REPLETE with functional enzymes. What most creationists curiously insist it isn't, when they claim endlessly that almost all mutations are "loss of function" or "loss of information" mutations that almost always inevitably break protein function.
Make SENSE of it please.
Here are a few selected publications for you to rationalize away:
http://www.pnas.org/content/early/2013/06/12/1308215110.abstract
Experimental evidence for the thermophilicity of ancestral life
Oh look, they resurrect a 3.5 billion year old enzyme using orthologous sequences spread out over many Archaeal and Bacterial lineages, statistically inferred the ancestral sequence from which they all evolved. Reconstructed the protein sequence and spliced it into a bacteria which then proceeded to express it. They then purified the enzyme and tested it's properties. Turns out it worked extremely well and was highly thermostable. This is despite almost the entire amino acid sequence of the protein being different from it's extant descendants.Abstract
Theoretical studies have focused on the environmental temperature of the universal common ancestor of life with conflicting conclusions. Here we provide experimental support for the existence of a thermophilic universal common ancestor. We present the thermal stabilities and catalytic efficiencies of nucleoside diphosphate kinases (NDK), designed using the information contained in predictive phylogenetic trees, that seem to represent the last common ancestors of Archaea and of Bacteria. These enzymes display extreme thermal stabilities, suggesting thermophilic ancestries for Archaea and Bacteria. The results are robust to the uncertainties associated with the sequence predictions and to the tree topologies used to infer the ancestral sequences. Moreover, mutagenesis experiments suggest that the universal ancestor also possessed a very thermostable NDK. Because, as we show, the stability of an NDK is directly related to the environmental temperature of its host organism, our results indicate that the last common ancestor of extant life was a thermophile that flourished at a very high temperature.
http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001446
Reconstruction of Ancestral Metabolic Enzymes Reveals Molecular Mechanisms Underlying Evolutionary Innovation through Gene Duplication
Abstract
Gene duplications are believed to facilitate evolutionary innovation. However, the mechanisms shaping the fate of duplicated genes remain heavily debated because the molecular processes and evolutionary forces involved are difficult to reconstruct. Here, we study a large family of fungal glucosidase genes that underwent several duplication events. We reconstruct all key ancestral enzymes and show that the very first preduplication enzyme was primarily active on maltose-like substrates, with trace activity for isomaltose-like sugars. Structural analysis and activity measurements on resurrected and present-day enzymes suggest that both activities cannot be fully optimized in a single enzyme. However, gene duplications repeatedly spawned daughter genes in which mutations optimized either isomaltase or maltase activity. Interestingly, similar shifts in enzyme activity were reached multiple times via different evolutionary routes. Together, our results provide a detailed picture of the molecular mechanisms that drove divergence of these duplicated enzymes and show that whereas the classic models of dosage, sub-, and neofunctionalization are helpful to conceptualize the implications of gene duplication, the three mechanisms co-occur and intertwine.
Here's a nice subject overview:
http://pages.uoregon.edu/joet/thornton-NRG-2004.pdf
RESURRECTING ANCIENT GENES: EXPERIMENTAL ANALYSIS OF EXTINCT MOLECULES
Joseph W. Thornton
There are few molecular fossils: with the rare exception of DNA fragments preserved in amber, ice or peat, no physical remnants preserve the intermediate forms that existed during the evolution of today’s genes. But ancient genes can now be reconstructed, expressed and functionally characterized, thanks to improved techniques for inferring and synthesizing ancestral sequences. This approach, known as ‘ancestral gene resurrection’, offers a powerful new way to empirically
test hypotheses about the function of genes from the deep evolutionary past.
No, because no other singular hypothesis fully explains all the properties of the dataset complete with predictive and explanatory power.lifepsyop said:Why? Because Rumraket and Douglas Theobald assert it should be different if a designer did it.
I'm not talking about similar types of animals. I'm talking about the gene sequences OF ALL LIFE. ALL their gene sequences, even those which are NOT physiologically constrained. Like enhancer and promotor regions. And then there's all the pseudogenes and ERV insertions. Just what the fuck is the purpose of all those degrading reverse-transcriptase genes again? Why do the mutations they accumulate ALSO form a massively statistically supported nested hierarchy? Why would a designer-recreate a dead AND useless gene? Why would the designer just constantly re-create this gene in a species over and over again every time "he" made a new one, and then mutate it further?lifepsyop said:You have not elucidated any scientific reason why we should expect similar types of animals to group chaotically if Common Descent is false.
Explain it.
No, not that it SHOULD, but that it would be MUCH MORE LIKELY.lifepsyop said:From your Theobald quotes:
Here we go again. Because it's 'possible' for similar morphology to be constructed differently on a molecular level, then that it means it *should* appear that way if Common Descent didn't happen.DL Theobald said:There is no known biological reason, besides common descent, to suppose that similar morphologies must have similar biochemistry. Though this logic may seem quite reasonable initially, all of molecular biology refutes this "common sense" correlation. In general, similar DNA and biochemistry give similar morphology and function, but the converse is not true—similar morphology and function is not necessarily the result of similar DNA or biochemistry. The reason is easily understood once explained; many very different DNA sequences or biochemical structures can result in the same functions and the same morphologies.
It really does say a lot that straightforward, logically valid probabilistic reasoning is "mysticism" in maginmandunnit-land.lifepsyop said:Unadulterated Darwinian Mysticism at work here.
That's good mate. Show me your nested hierarchies.lifepsyop said:I design 3D artwork on computers. I have created thousands of unique models and painted textures. There are many different methods and styles in how a complex 3D object is modeled, how its UV's (or its skin) is laid out flat to be painted, and especially how it is textured in a painting program.DL Theobald said:As a close analogy, consider computer programs. Netscape works essentially the same on a Macintosh, an IBM, or a Unix machine, but the binary code for each program is quite different. Computer programs that perform the same functions can be written in most any computer language—Basic, Fortran, C, C++, Java, Pascal, etc. and identical programs can be compiled into binary code many different ways. Furthermore, even using the same computer language, there are many different ways to write any specific computer program, even using the same algorithms and subroutines. In the end, there is no reason to suspect that similar computer programs are written with similar code, based solely on the function of the program.
Tell me, if you can take a thing from one of your designs and re-use it in another where it would work perfectly well too, would you then bother changing it? Would you do this EVERY TIME? (Those strange enhancer and promoter regions are back to haunt us here again).
Also, since many different biological structures can perform the same function, why would there be so many different versions? Why the hundreds of different eyes if just one works fine for most? If the same underlying genetical framework works just as well, why change it ever so slightly(as if by genetic drift) in a new lifeform?
Why all the silent or neutral changes that serve no purpose. Just what the fuck is the point of all the silent and neutral mutations which themselves fall into nested hierarchies? Was the designer TRYING to design an evolutionary pattern?
Yes, yes. You can keep rationalizing all of them "that's what the designer wanted". But so fucking many of them simply doesn't make sense. There'd be NO REASON to change them.
Ohh, quickly, efficiently and enjoyful. That's hilarious. Is your designer a human being? Is he constrained by time, a lack of resources, and subject to the boredom of mind and backstraining repetitive labor?lifepsyop said:Despite the theoretically possible millions of different ways to design these objects, I have my own distinct style, which allows me to proceed quickly, efficiently, and I enjoy it. I am not concerned with suddenly doing things completely differently all of the sudden, in case someone comes along and baldly asserts that my artwork arose by a series culled accidents.
Let's see what you wrote about your designer:
So you have no intention of putting forward alternative models.Hi Engelbert,
Since I've already stated I'm not interested in attempting to advance new scientific models, I'll respond to you on a more personal spiritual level. If I were you, I would honestly consider the possibility that Common Descent is false. I would consider the possibility that different kinds of lifeforms, even in their simplest molecular parts, are far too magnificently and functionally complex to have originated via culled genetic accidents or blind forces of any kind. I would suggest that different kinds of life had a Creator.
The Bible says that God is known by all men through the Creation and Conscience. God is known by the things that are made, and the sense of right and wrong written in our hearts. If I were in your position, questioning how the natural world came to be, I would consider the possibility that you already know the answer to this in your heart, and to humbly ask God yourself for further confirmation.
Oh wait, your alternative model is goddidit, as if a human being inadvertently making it look like evolution. That's just fucking brilliant dude.
Yes, the re-using of previous designs as templates. It is not at all common that these designs then fall masstively statistically attested into nested hierarchies. This almost never appens. It CAN be designed on purpose, but this is actually quite rare.lifepsyop said:In fact, this is a common pattern amongst nearly all human designers.[/b]
I agree, then why the fuck didn't your designer do that. Why did he recreate useless and dead reverse-transcriptase genes over and over gain, and further mutate them every time?lifepsyop said:Unless we specifically set out to keep doing things differently, or are unhappy with our current designs, we prefer to re-use what we consider to be elegant, efficient and functional designs over and over and over again.
Oh wait, lemme guess. He was "unhappy" with the previous version. Is that it? You know the mind of god now? Why does god's unhappiness with his designs mysterously fall into a nested hiearchy? That's just his "taste"? Oh look, "it's what the designer wanted". :lol:
Why would he create, then re-use dead and broken pseudogenes, but also mutate them even further, when it is known that those mutations are silent and/or neutral. I.e. they have no physiological, developmental or adaptive effect on the organism? What's the point? Is he TRYING to make it look like evolution happened?
Why would he create, then re-use but keep mutating enhancer and promotor regions, when it is known that those mutations are silent and/or neutral. I.e. they have no physiological, developmental or adaptive effect on the organism? What's the point? Is he TRYING to make it look like evolution happened?
Why would he create, then re-use but keep mutating and changing transcription factors, when it is known that those mutations are silent and/or neutral. I.e. they have no physiological, developmental or adaptive effect on the organism? What's the point? Is he TRYING to make it look like evolution happened?
It doesn't. Human designs don't normally fall into nested hierarchies. And human beings certainly don't run around changing their designs for no reason just to produce nested hierarchies. They certainly don't clutter their designs with random junk and then keep copying that junk and mutating it.lifepsyop said:Isn't it interesting that the Design argument you and Theobald are using goes against everything we know about observed Designers?
If you've already designed a mechanism for switching transcription on and off. Why would you keep mutating elements of the switching mechanism every fucking time you made a new organism? What's the point? Are you TRYING to make a nested hierarchy on purpose?
Thank you for your preachy but irrelevant statement of faith in scripture. Allow me to translate it into picture form:lifepsyop said:If someone chooses to believe these absolutely magnificent designs of nature arose by accident, then they intensely desire to ignore the obvious and believe lies. Romans 1:20 continues to become more and more fulfilled with each advance in modern Biology.
For the invisible things of him from the creation of the world are clearly seen, being understood by the things that are made, even his eternal power and Godhead; so that they are without excuse: