Rhed said:And I quote, "Therefore, on average a viral genotype carrying two beneficial mutations does not get the entire benefit individually associated with each mutation.
Rumraket said:And there we have it, you missed the key word. On average.
The total average effect of all double mutants was antagonistic, because the observed fitness was lower than the observed fitness of either single mutant
IT WAS HOWEVER STILL SYNERGISTIC (W[sub]ij[/sub] > W[sub]i[/sub] or W[sub]j[/sub]) IN SOME FEW CASES FOR DOUBLE DELETERIOUS MUTANTS, AND STILL BENEFICIAL (W[sub]ij[/sub] >1) IN SEVERAL MORE.
Rhed said:Indeed, when epistasis is decompensatory, both beneficial alleles involved in the interaction cannot spread to fixation in the population".
Rumraket said:Because their combination is less fit than their product, but this simply implies both single mutants are present, instead of a scenario where a double mutant arises against a background of no beneficial single mutants.
The only person missing the point is you. This is astonishing that you believe this research helps evolution in some way. Do you really believe that evolution is to work by a single stepping stone (mutation) at a time?!! Let me copy and paste the conclusion again, so everyone knows, so you don't twist this any further:
“Indeed, when epistasis is decompensatory, both beneficial alleles involved in the interaction cannot spread to fixation in the population, because the double mutant is less fit than each single mutant"
Only one "beneficial" mutation is able to be fixed into a population. Even if the two "beneficial" mutations were able to be fixed into a population, that still doesn't even come close to what evolution predicts. If a virus has a hard time evolving a new mechanism (which this experiment showed that it cannot with double mutants), how do you explain a single cell turn into a giraffe in the evolutionary time span given?!!!
And how about small populations that makes up most of the animal kingdom? For example, according to ToE humans and apes shared a common ancestor 10 million years ago. If we have a generation of 20 years, that would be 500,000 generations. Humans have 3 billion base pairs long and 95% identical to a chimp, which means we are 5% different. So 3 billion * .05 = 150 million base pairs different. So doing the math, you need 300 mutations fixed per generation.
So you are going to lecture me about how I don't understand the implications about this paper let alone evolution? These observations prove that the theory of evolution does NOT happen. Natural selection and single (maybe sometimes double) mutations are able to change an organism within its kind but obviously has a limit.
Evolution is faith-based; not scientific. And blind faith at that.