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Genetic engineering of humans

DerGegner

New Member
arg-fallbackName="DerGegner"/>
Now that I'm finally posting here I have to bring up this topic

I see a thread in Religion / Irreligion where someone wants to ban religion

I don't really think that would solve anything. In fact, a ban on religion would be despised and widely, easily flouted. Fortunately, I don't think religion is really the root cause of a lot of our problems either

If you'll forgive me for making a personal digression, I started to be distressed by the failings of society around the age of eleven or twelve. I grew up in a poor neighborhood and there was a lot of tension between the student body and the faculty. It was an unhealthy, overcrowded environment. A number of the faculty were frankly sadistic ... in retrospect the conditions were not unlike those of some prisons. I eventually had a mental breakdown in this school as a result of gratuitous faculty sadism and was committed for some time afterwards

Since then the issue of why people are such twats has occupied me almost obsessively. I don't think my anecdote is too parochial. Folks do an awful lot of stupid shit. Folks do an awful lot of stupid shit to each other. Quite frequently with wanton malice. They can do good or even great things, too, (under certain circumstances) but I think it's possible to do better. I can't say I was never one of those twats either: I have been. I stopped eventually, but I have been one of them. However, many people keep being assholes well into adulthood

Ideally, everyone would get along. That's the whole point of having a society. I would posit an evolutionary explanation for being a twat then. I know they're overly fashionable but it seems reasonable, at least. The kind of utility function we have for our society is probably very different from the ecological utility function according to which we evolved. Whether or not this is the case isn't terribly important for my purposes. People are twats in any case

Genetic engineering could remedy some of the ills of being a twat. Genes of course do not singularly determine someone's behavior: they just code for some RNA segment or protein, some of which play a role in how the brain develops. I don't think it would be good for society to define someone's behavior too rigidly and that's not possible anyway. Behavior is the interaction of biology and environment. (The late Herbert Simon had a nice analogy about this involving an ant walking on a beach.) So, holding environmental factors constant, manipulating genetic factors could increase someone's productivity as a citizen. I think that's a fairly uncontroversial claim, especially as we learn more and more about the brain and the gene expression involved

I have no idea whether philhellenes of YouTube fame posts here but, in any case, his latest video mentions the problem, if not my own peculiar solution

http://www.youtube.com/watch?v=BIT3TYnQJQc#t=6m52s

"The biggest problem [in achieving interstellar civilization] ... is us, and the ape that we each carry inside: our territoriality, our determination to breed beyond the land's ability to support us, our greed, our short-sightedness, our fear and hatred of those of a different tribe, our insane economic systems, our drive to war, our inability to face reality, these are the real challenges. By comparison, reaching the stars is easy."

It's rather sad how he outlines it, isn't it? From my perspective at least, he draws attention to two economic phenomena worth knowing in this case in a sort of tacit visceral way: opportunity cost and omission bias. They're somewhat related I think. Opportunity cost is the more well known of the two: it's the cost you incur by doing one thing rather than another, when you have to make an exclusive choice. Here's a good example. It's not mine, of course:
Opportunity cost contrasts to accounting cost in that accounting costs do not consider forgone opportunities. Consider the case of an MBA student who pays $30,000 per year in tuition and fees at a private university. For a two-year MBA program, the cost of tuition and fees would be $60,000. This is the monetary cost of the education. However, when making the decision to go back to school, one should consider the opportunity cost, which includes the income that the student would have earned if the alternative decision of remaining in his or her job had been made. If the student had been earning $50,000 per year and was expecting a 10% salary increase in one year, $105,000 in salary would be foregone as a result of the decision to return to school. Adding this amount to the educational expenses results in a cost of $165,000 for the degree.

So, you could say, "Well I think society is already improving. We don't need to tweak our genetics." Maybe it is. But I think we'd still be forgoing considerable gains not to use GE. If we rely on education and other environmental factors to improve welfare then we are building rather impressive hacks on a Stone Age brain ... but these are still jerry-rigged improvements, prone to break down. The other phenomenon is omission bias, which is the idea that errors of commission (fucking something up) and errors of omission (not doing anything) are normatively equal, other things being equal. You may well have balked at Jenny McCarthy's unlettered drivel about vaccines causing autism in recent months. But suppose vaccines caused autism very rarely. What would be worse? Withholding vaccines that stop once deadly illnesses in their tracks or the occasional case of autism or other illness? For whatever reason, people see an error of commission as worse than an error of omission which, in a utilitarian sense, is equal. It really isn't though, I think. And if it could be shown that withholding GE from humanity would be equivalent to shattering everyone's kneecaps then piercing their eardrums with chopsticks (comical but perhaps not too far-fetched given the way things are now) then I think we'd definitely be committing an error if we held back

What is the ideal human in my eyes? Well some amount of variance in character traits would probably be necessary, like a kind of genetic portfolio, but factors where definite genetic / neural influences are being exposed over time are hostility, agreeableness, different kinds of intelligence, to name a few. An ideal person would be very intelligent, but not brutal or cunning, and nearly incapable of anger ... it's a fairless useless emotion in a modern society. Very agreeable too, but it's sort of hard to say whether introversion or extroversion is more preferable. It could go either way. Skin color, etc. are of course normatively irrelevant

Now, I do have a rather strong conviction in my belief. I haven't looked hard enough for evidence that might change it and so I ask the reader to challenge me in my belief. (For once, this is much more than a thinly-veiled attempt to start a troll thread.)
 
arg-fallbackName="EvolvedMind"/>
I am so facinated with this subject (genetic engineering).
I am most definitely in favour of genetically engineering-away our faults.
:D
 
arg-fallbackName="LogosSteve"/>
Very good post DerGegner although I think you rambled a bit.

There is absolutely no real reason not to use genetic engineering to improve our species. What will stop us from doing this is exactly what philhellenes talks about in the video you referenced: our shortsightedness, more specifically the tendency to be afraid of changing what makes us who we are because of our ego. The common religious phrase used against the idea is that doing so would be "playing god" but in reality we "play god" every day when we use our knowledge to improve our survivability. And in the end that is what gets us closer to being "god."
 
arg-fallbackName="Unwardil"/>
Well, broadly speaking, I think the same mechanism that leads people to be twats also makes life enjoyable. Perversely, if we didn't have twats in the world, how would we recognize the non-twats?

But no, I think the problem, if you can call it that, runs deeper than simple genetics, I think it's an attribute of organisms, as it were, to be alive is to exist on a kind of continuum of twatness and that the way we recognize this not because of some absolute value of twat, but it is measured in relative terms.

The same way we can say pretty safely that a dolphin is more intelligent than a salmon, but we can't say that it's because a dolphin has an intelligence of 500 whereas a salmon only 46.

So it is the discrepancy of twatacity which is observable to us and no matter how much you engineered people towards the twatless end of the spectrum, you're always going to have bigger twats than others.


Now all that said, I think it's a fantastic idea, the trouble is, there's a lot of just engineering troubles. We could code for bigger brains, but children are already born so brainy that most women undergo C-sections just to squeege the little bastard out. Any brainier and it would be impossible to give birth to the child without medical care which isn't the biggest problem in the world until civilization collapses and we all go extinct in exactly 1 generation because the entirety of the next generation and their mothers (literally) die in child birth.

So now we have to also code for bigger hips in women to accommodate the wider birth canal but oh damn, that's connected to the hips which are already at a critical stress point as it is, given that most people's hips start acting up not too late in life, not to mention knees which are a fucking travesty of genetic incompetence. Anything with a rotator cuff really is a fucking liability...

Anyway, soon enough, you end up with something that, while genetically 'superior', bares more resemblance to a Dahli painting than to a human and within 7 to 10 generations will probably be completely infertile.

I think it'd probably be best to limit human GE to preventative treatment rather than trying to make us smarter or faster or less of a twat. Things like activating the gene that gives immunity to HIV, or deactivating the genes that cause MS. I'm absolutely 100% behind that kind of thing, but until we're actually ready to move into full controlled habitats where everything in the environment is artificially regulated, I think going too much further than that is asking for it to come back and bite us in the ass. Once we DO reach that state of course, hell, go for it, cause if civilization falls then, we'd be dead anyway.
 
arg-fallbackName="Aught3"/>
We are so far away from being able to do this, it's basically science fiction atm.
 
arg-fallbackName="Commander Eagle"/>
Aught3 said:
We are so far away from being able to do this, it's basically science fiction atm.

It might be possible, but it would be a long time before we reached that point, yeah.

There are basically two ways that this might happen. The first is that you could alter a person's genes after conception, and the second is that you could choose which genes a person would receive when they are conceived.

Altering someone's genes after conception is pretty much impossible. Looking at a baby in the womb - or a grown man - and saying "I think I'd prefer that you have red hair" would require a total re-write of all the genes in that person's body. All the DNA would have to be remade. The only way to do this would be to break down the DNA chains and insert whatever you wanted in there. Somehow I doubt that this would be possible without killing the subject. And, once the subject is dead, this is basically equivalent to the second option.

Because the second option requires that you control the reproductive process entirely. When mommy and daddy throw their genes together to make babby, it's pretty difficult to determine exactly which genes daddy donates. Ditto for mommy. The only way to really circumvent this is to make sure that a specific egg meets up with a specific spermatozoa, and that each contains exactly the genes that are desired. But the only way to do that would be to control their formation.

Essentially, the only way to completely engineer a human's genome would be to create them, base pair by base pair, in a vat. Theoretically there's no issue with this, but practically, this requires incredibly advanced machinery which we simply don't have at the moment, as well as a total understanding of the entirety of human genetics (which we also don't have).

So no genetic engineering to solve humanity's problems just yet, I'm afraid. For now, we're just going to have to make do with mocking the dickheads of the world via internet message boards.
 
arg-fallbackName="MRaverz"/>
The problem with eugenics and other forms of genetically 'improving' a species, is that it's near impossible to determine what a 'perfect human' would be. As such, you state that a perfect human for you would have all it's points in intelligence, but none in cunning, anger etc. Such a classification brings up issues regarding whether you could consider such a being to be 'human' and if not, whether or not you were essentially condoning genocide.

However, I'm going to properly address the practicality more than the philosophy. As such, there are a number of issues: objectively determining the 'good' factors, unforeseen issues related to the removal or insertion of a gene, ethics regarding people who may not want to be genetically altered and the process of actually genetically altering someone.

When considered casually, it would seem that there is nothing wrong with wanting to improve your own species, yet the reality of the situation is that practically it's a highly complex process which we may not ever be capable of and ethically, you're talking about changing the identity of people without their permission, as I expect the majority of genetic alteration would need to take place during early development.


Edit: As such, there's also the possibility that certain traits, such as cunning and anger, are actually beneficial to society in general. Removal of such traits could spell our demise. The best solution is to live with humanity's failings and use them to humble ourselves. If we suddenly became a super-race, our bloated sense of self-importance would be magnified.
 
arg-fallbackName="lrkun"/>
EvolvedMind said:
I am so facinated with this subject (genetic engineering).
I am most definitely in favour of genetically engineering-away our faults.
:D

Welcome to the forums.

---

I support human genetic engineering. The problem is theists will disagree. Theistic docrtine says that only god can create. Therefore, until the issue of only god can create is resolved, this remains fiction.

I still hope it will happen sooner if not later.
 
arg-fallbackName="aeritano"/>
Aught3 said:
We are so far away from being able to do this, it's basically science fiction atm.

its actually quite possible and is being done right now :p

Genetic engineering has been happening since we were able to begin transgenics on mice we have been genetic engineering human cells in culture.

Once i can get the presentation i gave at UCSF up on YT (Damn storms are making it hard to maintain a decent connection), go watch it and i talk about therapeutic uses of reprogrammed stem cells :p
 
arg-fallbackName="Aught3"/>
aeritano said:
its actually quite possible and is being done right now :p

Genetic engineering has been happening since we were able to begin transgenics on mice we have been genetic engineering human cells in culture.

Once i can get the presentation i gave at UCSF up on YT (Damn storms are making it hard to maintain a decent connection), go watch it and i talk about therapeutic uses of reprogrammed stem cells :p
Really? We know the genes that control the level of twatiness and are altering them as we speak :|
 
arg-fallbackName="Aught3"/>
Unwardil said:
Aught3 said:
Really? We know the genes that control the level of twatiness and are altering them as we speak :|

It's spelled "twatacity".
IDK, I just did a Google scholar search and got more hits with twatiness than with twatacity.

Twatacity: (n) the really irritating form of tenacity.
 
arg-fallbackName="Don-Sama"/>
Genetic engineering on the scale and level your speaking of isn't that far away, the question is if we as humans are ready for such technologies, it might be wise to stop or slow down these technological possibility's and progression.

what your talking about it completely changing a human being, from the very bottom, the very basis of it all. you describe to you inferior human beings, is your meaning justified? as you said you were once one of them, due to what factors, experiences did you stop? you seem to see all humans as the simple ones you have surrounding you, the ones you have grown up with. you seem to dismiss all cultural differences and variations. even to our ''economical'', yet you forget such things as communism in which the economical system was so very different. on how much is our behaviour based on genetics, and how much on culture itself?

Even if alot of out behaviour is based on our genetics I still do not think we should mess with the very basics of it all. Genetic Engineering is very scary, very new. there has to be drawn a line at some point I'm not sure where it is yet...
 
arg-fallbackName="aeritano"/>


There ya go Aught3 :p

engineering stem cells to convey resistance to diseases or to grow new tissue
 
arg-fallbackName="Aught3"/>
Thanks for the effort but my internet sucks so I can't really watch an hour and a half webinar but,
aeritano said:
engineering stem cells to convey resistance to diseases or to grow new tissue
This is fairly easy stuff in comparison to predictably altering subtle traits of human personality, that's what we're talking about right?
 
arg-fallbackName="Cnidarious"/>
I`ve got no problems with this whatsoever.

and quite allot of hype regarding this is just fear mongering.
If it persists the effect it will have is Stagnation, keeping medical advances from being
made. It REALLY dosent need negative attention that the far could pick up on and rally against.

Nobodies going to be recreating the scinario from the movie "the island"
and nobody is making frankentstein.
 
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